Isekai stories involve one or more characters being transported to another world.
In concept, it's a very old framing device for stories, though in the modern day, people tend to associate isekai with light novels, manga, and anime that often involve virtual reality or protagonists being reborn in a parallel world, rather than entering through portals, magical doorways, or being summoned by outside forces.
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Protagonists are the lead characters in a story.
Isekai stories involve one or more characters being transported to another world.
In concept, it's a very old framing device for stories, though in the modern day, people tend to associate isekai with light novels, manga, and anime that often involve virtual reality or protagonists being reborn in a parallel world, rather than entering through portals, magical doorways, or being summoned by outside forces.